Scaffold-based Anti-infection Strategies in Bone Repair
نویسندگان
چکیده
منابع مشابه
Biofunctionalized Scaffold in Bone Tissue Repair.
Bone tissue engineering is based on bone grafting to repair bone defects. Bone graft substitutes can contribute to the addition of mesenchymal stem cells (MSCs) in order to enhance the rate and the quality of defect regeneration. The stem cell secretome contains many growth factors and chemokines, which could affect cellular characteristics and behavior. Conditioned medium (CM) could be used in...
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Tissue engineering scaffolds with a micro- or nanoporous structure and able to deliver special drugs have already been confirmed to be effective in bone repair. In this paper, we first evaluated the biomineralization properties and drug release properties of a novel mesoporous silica-hydroxyapatite composite material (HMS-HA) which was used as drug vehicle and filler for polymer matrices. Biomi...
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Background: Bone tissue engineering requires materials that are biocompatible, mechanically suited for bone function, integrated with the host skeleton, and support osteoinduction of the implanted cells for new bone formation. The aim of this study was to compare the osteogenic potential of xenograft with hydroxyapatite/β- tricalcium phosphate (HA/β-TCP) scaffold. Methods: New Zealand rabbits (...
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The limitations of current grafting materials have driven the search for synthetic alternatives to cancellous bone. A variety of biodegradable polymer foams composed of poly(lactide-coglycolide) [PLAGA] have been evaluated for such uses. However, structural limitations may restrict the clinical use of these scaffolds. We have developed a sintered microsphere scaffold composed of 85:15 poly(lact...
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ژورنال
عنوان ژورنال: Annals of Biomedical Engineering
سال: 2014
ISSN: 0090-6964,1573-9686
DOI: 10.1007/s10439-014-1205-3